[Reaction on 'Minocycline for schizophrenia: a brief overview'].
نویسندگان
چکیده
LITERATUUR • Fatemi SH, Folsom TD. The role of fragile X mental retardation protein in major mental disorders. Minocycline supplementation for treatment of negative symptoms in early-phase schizophrenia: a double blind, randomized, controlled trial. model interessante behandelopties naar voren kunnen komen die een bredere toepassing binnen de algehele
منابع مشابه
A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia.
BACKGROUND Current antipsychotics have only a limited effect on 2 core aspects of schizophrenia: negative symptoms and cognitive deficits. Minocycline is a second-generation tetracycline that has a beneficial effect in various neurologic disorders. Recent findings in animal models and human case reports suggest its potential for the treatment of schizophrenia. These findings may be linked to th...
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Background: Minocycline is a second-generation tetracycline with apparent neuroprotective effects. It reportedly blocks the activation of microglia, preventing the release of cytokines that are believed to contribute to schizophrenia. Minocycline also helps to maintain normal glutamatergic neurotransmission. Although the exact mechanism is unknown, results of animal studies and several human tr...
متن کاملMinocycline for Schizophrenia: A critical review
Minocycline, an antibiotic of the tetracycline family, has been shown to display neurorestoractive or neuroprotective properties in various models of neurodegenerative diseases. In particular, it has been shown to delay motor alterations, inflammation and apoptosis in models of Huntington’s disease, amyotrophic lateral sclerosis and Parkinson’s disease. Despite controversies about its efficacy,...
متن کاملEffects of minocycline add-on treatment on brain morphometry and cerebral perfusion in recent-onset schizophrenia.
Increasing evidence suggests that the tetracycline antibiotic minocycline has neuroprotective effects and is a potential treatment for schizophrenia. However, the mechanisms of action of minocycline in the CNS remain elusive. The aim of this study was to investigate the effects of minocycline on brain morphology and cerebral perfusion in patients with recent-onset schizophrenia after 12months o...
متن کاملPossible antipsychotic effects of minocycline in patients with schizophrenia.
We present two cases of patients with schizophrenia treated with minocycline. Minocycline (a second-generation tetracycline) is an established and safe broad-spectrum antibiotic that crosses the blood-brain barrier, with additional efficacy for diseases such as acne and rheumatoid arthritis. Animal studies have suggested that minocycline may prevent progression of some neurological disorders. M...
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ورودعنوان ژورنال:
- Tijdschrift voor psychiatrie
دوره 56 8 شماره
صفحات -
تاریخ انتشار 2014